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Vulva pagets disease recurrence in rectum

Vulvar Paget's disease is very rare malignancy originating in vulvar apocrine-gland-bearing skin cells or as a manifestation of adjacent primary anal, rectal or bladder adenocarcinoma. Vulvar Paget's disease is most commonly seen in postmenopausal Caucasian females and appears clinically as red, eczematous and pruriginous — and sometimes painful — lesions. In most cases it is an intraepidermal adenocarcinoma in which tumor cells involve the epidermis and sometimes the underlying skin appendage, but sometimes there is focal dermal invasion. Probably because of its multicentric nature, Paget's disease has a chronic and relapsing course. Surgery has been the treatment of choice, but disease frequently extends far from the visible lesion and surgical margins are frequently positive. The Paget's cells are larger than keratinocytes, have clear chromatin, a prominent nucleolus and gray—blue cytoplasm and they may appear vacuolated with hematoxylin and eosin staining. Many patients undergo multiple surgical procedures, including wide local excision, simple vulvectomy or radical vulvectomy.
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Clinical treatment of vulvar Paget's disease: a case report

Vulva pagets disease recurrence in rectum
Vulva pagets disease recurrence in rectum
Vulva pagets disease recurrence in rectum
Vulva pagets disease recurrence in rectum
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Extramammary Perianal Paget's Disease

Extramammary Paget disease of the skin is a rare intraepithelial cancer characterised by a chronic eczema -like rash around the axillae or anogenital regions of males and females. Extramammary Paget disease most commonly occurs in the vulva of women aged between 50—60 years. It can also affect the axilla and the anogenital area in males of similar age. It has been observed that it is more common in Asians than in Europeans and very rare in African-Americans.
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Extramammary Perianal Paget's Disease

Perianal Paget's disease is a rare malignancy. It is rarely isolated and often associated with an underlying adenocarcinoma. It usually presents with anal itchiness and discomfort and can be misdiagnosed as hemorrhoids. Once the diagnosis of perianal Paget's disease is granted, extensive work-up to find an underlying primary malignancy is crucial.
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Use the link below to share a full-text version of this article with your friends and colleagues. Learn more. The vulva is the most common site of involvement but any area of the anogenital skin can be affected. Due to its rarity, variable clinical course and deceptive histological appearance it has a high misdiagnosis rate and both gynaecologists and dermatologists have limited experience in its management. The significance of the disease lies in its association with underlying malignancy as well as its inherent ability to invade the dermis and metastasise.
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